L10-L14: Bullous disorders

L10: Pemphigus

Pemphigus is a group of rare, chronic autoimmune skin disorders that are characterized by the development of blisters and sores on the skin and mucous membranes. These conditions occur when the immune system produces antibodies that attack the proteins in the skin and mucous membranes, causing them to separate from each other and form blisters. The exact cause of this immune response is unknown, but it may be triggered by certain medications, UV light, or physical trauma. The blisters of pemphigus are usually painful, but not itchy, and they may burst and become open sores that can get infected. Other symptoms may include blisters in the throat, mouth, or nose, skin rash, and fever. The progression of the disease can vary, but without treatment, the blisters can spread and become more severe. In severe cases, the blisters can cover a large area of the skin and may be life-threatening.