U85: Resistance to antineoplastic drugs

The group of conditions classified under resistance to antineoplastic drugs refer to instances where certain cancer-fighting medications, known as antineoplastic drugs, become less effective in controlling or reducing the growth and spread of cancer cells. These conditions usually occur when cancer cells adapt to the presence of these medications, developing mechanisms to evade their effects, like pumping the drugs out of the cells before they can act, repairing the DNA damage caused by these drugs, or modifying the drugs to make them less harmful. Common signs of this phenomenon include a decrease in the effectiveness of cancer treatment, recurrence of cancer after initial remission, or the cancer continuing to grow despite treatment. The progression of these conditions largely relies on the type of cancer and the specific antineoplastic drugs used, among other individual factors. Such resistance predominantly affects the body's ability to combat and control cancer, impacting the overall patient prognosis.