Q81.1: Epidermolysis bullosa letalis

The skin is made up of various layers. Normally the various layers of skin hold tightly together. This condition changes the genetic make-up so that certain components of the skin cells are no longer formed properly. This results in the layers of skin not being held together so tightly. The layers of skin no longer holding together so tightly can cause various symptoms.

The condition causes blisters to form on the skin. The blisters can form, for example, on light tough, bumping, heat or without any external reason. The blisters can burst easily and then leave wounds and sores behind. The wounds heal poorly and can also become inflamed. Scars may remain and adhesions develop.

Hair or toenails and fingernails can also be damaged by the condition. Hair can fall out in patches or completely. The condition can also cause damage to the teeth.

The condition can also affect the eyes. Inflammation and scars can develop in different areas of the eyes, for example. It is also possible to go blind. Blisters can also form on the moist membranes of things like the windpipe, stomach or intestines. Scars may also develop. This causes difficulties with eating or digestion. The airways being affected can then also make you hoarse or have problems breathing. It is also possible for there to be fewer red blood cells in the blood than normal. You may also not grow properly. The condition makes you seriously ill.

This disease is hereditary. Family members can also be affected.