M90.4: Osteonecrosis due to haemoglobinopathy

Osteonecrosis due to haemoglobinopathy is a specific medical condition associated with certain blood disorders, wherein the blood supply to the bone is disrupted, leading to the death (necrosis) of bone tissue. The bone affected may eventually collapse, causing pain and limited range of motion. This condition is often observed in individuals with haemoglobinopathies, a group of disorders that affect the oxygen-carrying molecule, haemoglobin, in the blood. The interruption in blood flow to the bones can result from abnormal haemoglobin, which can cause blood cells to stick together and block blood vessels. Often, individuals with this condition experience joint pain, tenderness, and bone weakness. The hip, shoulder or knee are commonly affected areas, although osteonecrosis can occur in any bone. Despite being a progressive disease, its advancement rate can vary, with some individuals experiencing rapidly progressing bone damage, while others have a more gradual progression.