M80.4: Drug-induced osteoporosis with pathological fracture

Drug-induced osteoporosis with pathological fracture is a single medical condition where medications cause the bones to become weak and brittle – to such an extent that even mild activities such as bending over or coughing can lead to fractures (pathological fractures). Most commonly, it causes fractures in the spine, hips, or wrists. This condition occurs when certain types of medications interfere with the body's normal process of breaking down and rebuilding new bone tissue. As a result, the bones lose their density, making them more vulnerable to fractures. The disease progression varies and largely depends on the type and duration of the drug causing the osteoporosis and other individual health factors. The symptoms and signs may not be noticeable until a bone fracture occurs, although some people may experience bone pain or tenderness, and height loss due to previous fractures in the spine.