M30-M36: Systemic connective tissue disorders

M31: Other necrotizing vasculopathies

Necrotizing vasculopathies refer to a group of medical conditions where inflammation and damage occurs to the blood vessels, specifically the walls of the blood vessels. The term 'necrotizing' refers to cell death or tissue death, indicating that these conditions can lead to severe damage. These diseases can affect blood vessels of all sizes, including arteries, veins, and capillaries throughout the body. Because of the vital role of blood vessels in transporting nutrients and oxygen, these conditions can have widespread effects across different body systems. Common symptoms include fever, fatigue, weight loss, muscle and joint pain, and nerve problems. These conditions may develop quickly or slowly depending on the specific type and individual. They may be triggered by the immune system mistakenly attacking healthy blood vessels, infections, or certain medications. The progression of the disease can vary widely from person to person, with some experiencing mild symptoms and others severe, life-threatening complications.