L51.2: Toxic epidermal necrolysis [Lyell]
Toxic Epidermal Necrolysis, also known as Lyell's syndrome, is a severe and often life-threatening skin condition. Often caused by an unexpected severe reaction to medication, toxins build up and cause the top layer of skin (the epidermis) to detach and die, leading to severe blistering and skin peeling, similar to a burn. This disease usually begins with unspecific symptoms like fever and discomfort, but rapidly evolves into severe blistering rashes. These extremely painful blisters cover a large extent of the body, sometimes as much as 30% or more, particularly affecting areas such as the mucous membranes in the mouth, eyes, and genitals. The severe skin loss exposes the underlying tissues and organs to the same risks as a major burn, such as infection, fluid loss, and changes in body temperature. While recovery can often take weeks to months, it's crucial to note that even after recovery, long-term complications can persist, including damage to the eyes and other vital organs.
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