E84.8: Cystic fibrosis with other manifestations

Cystic fibrosis with other manifestations (ICD-10 code E84.8) is a chronic, genetic disease that affects multiple body systems, usually including the respiratory and digestive systems, and in certain instances, may present other complications as well. This condition occurs due to a mutation in the CFTR gene, causing an abnormal transport of chloride and sodium across an epithelium, leading to thick, sticky mucus build-up. It may present various symptoms according to the affected body systems. The respiratory symptoms often include persistent coughing, difficulty in breathing, and frequent lung infections. Gastrointestinal symptoms consist of persistent constipation, difficulty in gaining weight, malnutrition, and inflammation of the pancreas. Since it's a genetic disorder, the disease can be passed down through generations. Therefore, a patient with this condition is likely to have inherited the defective gene from both parents. The disease often develops in early childhood and continues into adulthood, with symptoms typically becoming more severe over time.