E20-E35: Disorders of other endocrine glands

E31: Polyglandular dysfunction

Polyglandular dysfunction, as implied by the name, refers to a group of disorders caused by dysfunction in more than one gland in the body. This often results in an imbalance in hormonal activity, leading to a variety of symptoms which may vary widely depending on the specific glands involved. Common issues may arise from problems with glands such as the thyroid, adrenal, and pituitary. The underlying causes of these disorders can vary, but they generally stem from either genetic or autoimmune factors. In cases related to autoimmune issues, one's own immune system mistakenly attacks the body's glands, causing them to function improperly. Symptoms might include fatigue, changes in weight, depression, and irregular menstruation in women. This is usually a chronic condition that can progress over time, possibly leading to more serious health complications related to hormonal imbalances if not properly managed.