Y54: Agents primarily affecting water-balance and mineral and uric acid metabolism

Y54.3: Benzothiadiazine derivatives

Benzothiadiazine derivatives are a class of medications primarily utilized for their antihypertensive and diuretic effects. These medications work by inhibiting the reabsorption of sodium and chloride in the kidneys, which in turn increases the amount of urine produced and decreases the fluid in the blood vessels, ultimately lowering blood pressure. They're commonly used to treat conditions such as high blood pressure (hypertension), heart failure, and edema (fluid build-up in the body). In general, side effects may include frequent urination, dehydration, electrolyte imbalance, and in some cases, renal or kidney dysfunction if used improperly. Though generally well-tolerated, like all medications, benzothiadiazine derivatives should be used under the supervision and guidance of a healthcare provider.