R65: Systemic Inflammatory Response Syndrome [SIRS]

R65.2: Systemic Inflammatory Response Syndrome of non-infectious origin without organ failure

Systemic Inflammatory Response Syndrome (SIRS) of non-infectious origin without organ failure is a serious condition where the body's defense system goes into an overdrive. Unlike typical SIRS, this version is not caused by an infection. The body responds as if there is a severe infection when there isn't, leading to inflammation throughout the body. This general inflammation fails to localize or eliminate the cause of the disturbance, thereby leading to widespread changes in the function of many body systems. Notably, this particular type of SIRS does not involve organ failure. Symptoms often include fever or low body temperature, rapid heartbeat, and rapid respiration rate. Blood tests might show an increased or decreased number of white blood cells. It is a serious syndrome that requires immediate medical attention and is typically managed in a hospital setting.