M88: Paget disease of bone [osteitis deformans]
Paget's disease of bone, also known as osteitis deformans, is a medical condition that disrupts the typical process of bone renewal and repair. Patients' existing bone is broken down at an accelerated rate, and replaced with new bone tissue that is often enlarged, disordered, and structurally weaker. This disease can affect any bone in the body, but it often targets the spine, pelvis, skull, and long bones of the legs and arms. The cause of Paget's disease is still uncertain, but there is potential for genetic factors and viral exposures to contribute. Symptoms may include bone pain, joint pain, stiffness, and potentially deformity in some cases. Over time, this abnormal, rapid bone turnover can also lead to more serious complications like bone fractures, hearing loss (if the skull is affected), or increased pressure on nearby nerves. It's important to note that some people may have no symptoms at all, and Paget's disease may be discovered incidentally during an examination or test for another health issue.
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