M34: Systemic sclerosis

M34.1: CR(E)ST syndrome

With systemic scleroderma, the body produces too many connective tissue proteins. The connective tissue thickens and hardens as a result. This is probably caused by the body’s immune system. There is connective tissue all over the body. There is connective tissue beneath the skin and around muscles and organs, for example. Muscles and organs have connective tissue, too. The disorder can affect certain parts of the body or the body as a whole.

Systemic sclerosis comes in different forms. With this type of systemic sclerosis you can have difficulties swallowing and have small, hard nodules in your skin. Small veins may also appear on the skin. The blood vessels in your fingers might also contract more than usual in the cold. So the fingers turn white or blue.