M05: Seropositive rheumatoid arthritis

M05.3: Rheumatoid arthritis with involvement of other organs and systems

Rheumatoid arthritis with involvement of other organs and systems, designated by the code M05.3, is a progressive and systemic autoimmune disease. It primarily leads to chronic inflammation of the joints, resulting in painful swelling and eventual joint damage and deformity. However, in a significant number of patients, the disease goes beyond the confines of the joints. This means that it may affect other body systems such as the skin, heart, lungs, and eyes due to systemic inflammation. Symptoms may vary, including joint pain and stiffness, skin nodules, shortness of breath, dry eyes, and chest pain. The disease's course is unpredictable, with periods of increased disease activity called "flares" and times of relative remission. The cause of rheumatoid arthritis is not fully understood, but it is believed to involve a combination of genetic and environmental factors.