E88.3: Tumour lysis syndrome

Tumour lysis syndrome is a serious condition that can occur during the treatment of cancer, predominantly with chemotherapy or radiation therapy. This happens when cancer cells break down and release their contents into the bloodstream, leading to an imbalance of electrolytes, including phosphorus, potassium, and uric acid. This sudden shift can overload the kidneys, leading to potential kidney failure if left untreated. Common symptoms may include nausea, vomiting, irregular heartbeat, and shortness of breath. In severe cases, it can lead to seizures or even heart failure. It is more common in individuals who have large, fast-growing tumors, such as lymphomas and leukemias. The manifestation and severity of this condition largely hinge on the type of cancer being treated and how the body responds to cancer therapy.

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