E70-E90: Metabolic disorders

E79: Disorders of purine and pyrimidine metabolism

Disorders of purine and pyrimidine metabolism represent a group of conditions generally characterized by an imbalance in the body's handling of purines and pyrimidines, building blocks of our DNA and RNA. Various genetic mutations may be the root cause, leading to abnormal production, breakdown, or use of these molecules. The result is an over-accumulation or deficiency of certain substances in the body, causing a broad spectrum of symptoms. Typically, these conditions can manifest with a range of signs including developmental delays, mental retardation, physical impairments, skin disorders, and problems with the nervous system. The severity, age of onset, and progression of these conditions can vary significantly, largely dictated by the specific type of purine or pyrimidine disorder. Notably, these disorders can affect many organ systems in the body, encompassing the brain, kidneys, and skin among others.