E34: Other endocrine disorders

E34.5: Androgen resistance syndrome

Androgen resistance syndrome, also known as Androgen Insensitivity Syndrome (AIS), is a genetic condition where a person is born with male (XY) chromosomes but their body cannot use androgens, which are hormones responsible for male physical traits. The bodies of people with this disorder are insensitive to the effects of certain hormones called androgens. Even though they have the genetic makeup of a male, the insensitivity to these hormones may lead to physical traits that appear to be female or are between typical male and female. This condition can range from mild, where the individual may have minor changes in genital appearance, to severe, where the person has an entirely female appearance. Symptoms can include infertility, underdeveloped male genitalia, or a patchwork of male and female physical traits. This condition is inherited, passed down through families. Symptoms and physical traits can vary widely.