D82: Immunodeficiency associated with other major defects

Immunodeficiency associated with other major defects, as the term suggests, is a group of conditions where the immune system's ability to fight off infections and other diseases is compromised or entirely absent due to other significant health issues. These health issues can be congenital, meaning present at birth, or can develop later in life due to environmental factors or other diseases. When the immune system is weakened, the body is more susceptible to infections, which can be severe or even life-threatening. Common symptoms can vary greatly but often include frequent and recurrent infections, slow healing, fatigue, and weight loss. Disease progression is dependent on the underlying defects and the corresponding impact on the immune system. These conditions affect not only the immune system but also other systems in the body, depending on the associated defect.