C94.4: Acute panmyelosis with myelofibrosis

Acute panmyelosis with myelofibrosis is a severe and rare disease affecting the bone marrow, the primary site of blood cell production. In this condition, the normal bone marrow is replaced by cells that produce fibrous connective tissue, leading to a condition called myelofibrosis. At the same time, there is an uncontrolled increase in immature blood cells, or panmyelosis. This simultaneous occurrence is what sets this condition apart from others. Patients may experience symptoms such as fatigue, breathlessness, frequent infections, and abnormal bleeding or bruising due to the disruption in production of healthy blood cells. They may also experience pain or discomfort in the abdomen due to an enlarged spleen, which is a common feature of the disease. Because it progresses rapidly, it can worsen quickly without prompt and appropriate treatment.