C92.5: Acute myelomonocytic leukaemia

Acute myelomonocytic leukaemia, denoted by ICD-10 code C92.5, is a subtype of acute myeloid leukaemia, a form of blood cancer. The condition is characterised by a rapid increase in white blood cells, particularly the cells known as myelocytes and monocytes. When these blood cells become cancerous and start multiplying uncontrollably, they can interfere with the production of normal blood cells, leading to problems like anemia, infections, and excessive bleeding. Acute myelomonocytic leukaemia typically presents with non-specific symptoms such as fatigue, frequent infections, easy bruising or bleeding, and weight loss. Other symptoms may include bone pain and shortness of breath. Because this type of leukaemia progresses quickly, it can become life-threatening within a short period without treatment. It can occur at any age but is more commonly seen in adults. The exact cause is unknown, but factors such as genetic disorders, exposure to certain chemicals or radiation, and previous chemotherapy or radiotherapy may increase the risk. The condition is diagnosed by blood tests and bone marrow biopsy. Although the disease is severe, treatment including chemotherapy, stem cell transplants, and supportive care can help manage the condition.