C92.2: Atypical chronic myeloid leukaemia, BCR/ABL- negative
Atypical Chronic Myeloid Leukaemia, BCR/ABL-negative (aCML- BCR/ABL-negative) is a rare and unique subtype of chronic myeloid leukaemia – a cancer that affects blood-forming cells in the bone marrow. Unlike typical Chronic Myeloid Leukaemia, which is characterized by the presence of the Philadelphia Chromosome or the BCR/ABL gene fusion, the atypical variant lacks this genetic marker and hence is termed as BCR/ABL-negative. People with aCML- BCR/ABL-negative may experience symptoms such as fatigue, weakness, weight loss, and frequent infections due to an increase of abnormal white blood cells in the blood. The disease progression for aCML- BCR/ABL-negative is generally more rapid and aggressive compared to its typical counterpart. Despite being recognized as a distinct disease, its diagnosis can be challenging due to its overlapping characteristics with other myeloid disorders.
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