C92.1: Chronic myeloid leukaemia [CML], BCR/ABL-positive
Chronic Myeloid Leukaemia (CML), BCR/ABL-positive, is a type of blood cancer that originates from a genetic change in a stem cell, found in bone marrow. This mutation produces an abnormal protein, BCR-ABL, which leads to the rapid, uncontrolled growth of white blood cells, particularly a type called granulocytes. These granulocytes do not mature and function properly, and eventually accumulate in large numbers, disrupting normal blood cell production. It's considered a chronic condition because it typically progresses slowly over several months or years. Common symptoms may include fatigue, night sweats, weight loss, and discomfort or a sense of fullness in the upper left part of the abdomen. Over time, if untreated, this condition can cause damage to the bone marrow and other parts of the body. BCR/ABL-positive status refers to the presence of this particular gene mutation.
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